Supporting Hormonal Balance for Better Health with CelluThrive™

As we age, our hormone levels naturally fluctuate, impacting our health in various ways. Estrogen is an essential hormone for both men and women, influencing mood, energy, metabolism, bone health, and brain function. When estrogen levels become unbalanced—whether too high or too low—it can lead to a range of health concerns. While estrogen imbalances are often associated with women, particularly around menopause, it’s important to understand that estrogen affects men, too. Therefore, maintaining optimal hormone balance is a priority for any person’s overall well-being.

Why Does Estrogen Get Out of Balance?

Estrogen plays a significant role in the body, influencing the reproductive system along with bone health, heart health, and brain function. However, a build-up of excess estrogen can result in greater health concerns. For women, estrogen is primarily produced in the ovaries, whereas for men, smaller amounts are made, mainly through the conversion of testosterone in tissue like fat and muscle. The body produces three types of estrogen: Estrone (E1), Estradiol (E2), and Estriol (E3). Of the three forms, estradiol is the most prevalent and potent form for most of our lives. Elevated levels of estradiol can contribute to estrogen dominance, a condition that increases the risk of hormone-related health issues.

Complicating things further, we are exposed to all sorts of additional estrogen intake through diet, medications, and environment. For example, certain medications can introduce synthetic estrogens to the body [i]. In other cases, certain foods contain phytoestrogens— natural compounds found in plants and foods like soy, flaxseeds, hops, and dairy that have a similar chemical structure to estradiol [ii]. Lastly, pesticides, preservatives, and certain plastics can lead to the absorption of xenoestrogens—chemicals that mimic estrogens (specifically estradiol) in the body [iii]. We are up against a lot, and in order to maintain a healthy hormone balance, these various forms of estrogen need to be effectively metabolized to avoid accumulation that can contribute to estrogen dominance.

Impact on Women’s Health

For women, particularly in their 40s, 50s, and beyond, estrogen dominance can be a real disruption. During perimenopause and menopause, a woman’s body wants to naturally shift its predominant form of estrogen from E2 to E1. From this point on, estrone, a more stable, long-term form of estrogen, becomes the foundation for the subsequent stages of a woman’s life, providing strength, stability, and clarity for the years to come [iv]. However, this transition doesn’t feel as graceful as it should for many women. An imbalance of excess estradiol, compounded by other estrogen mimickers, can disrupt the healthy aging process, resulting in symptoms like low energy, mood swings, hot flashes, trouble sleeping, and more.

What about Men?

Often overlooked in hormone conversations: Estrogen isn’t just a “women’s hormone” — men also produce and need it (in much smaller amounts), primarily through the conversion of testosterone in fat tissue. But when estrogen levels in men get too high (estrogen dominance), it can disrupt hormonal balance and even suppress natural testosterone production [v].

Remove of Excess Estrogen With CelluThrive™

Let’s get to the solution. While many products exist that can help alleviate the hormone-related symptoms, few of them address the root causes of this imbalance. We might not think about the liver’s role in finding hormone harmony, but it just so happens that the liver is the central organ responsible for metabolizing and deactivating estrogen. While it may sound technical, the process, called glucuronidation, simply works in the liver to convert estrogens into inactive, water-soluble forms that can be excreted. However, there is a problem: certain gut bacteria in our body like to disrupt this process, resulting in the metabolized estrogen getting reabsorbed back into the bloodstream. When the free-form estrogen regains biological activity, it accumulates, contributing to estrogen dominance [vi]. This is where CelluThrive™ comes in!

CelluThrive™ is an enhanced form of D-Glucarate, a compound clinically studied to improve the efficiency of glucuronidation. This powerful ingredient is especially good at counteracting the impact that our gut bacteria has on estrogen reabsorption/reactivation. By inhibiting the bacteria’s enzyme activity (β-glucuronidase), CelluThrive™ helps the body effectively eliminate these metabolized compounds, allowing for a healthier hormonal balance.

Glucuronidation also helps remove other chemical compounds that are foreign to the body, including drugs, environmental pollutants, and even many food additives [vii, viii]. In fact, up to 75% of these xenobiotics are removed through glucuronidation [ix]. Therefore, the liver needs all the help it can get. Supplementing with CelluThrive™ ensures the effective elimination of harmful toxins and byproducts, allowing for a healthier system and promoting better cell vitality.

Clinically Supported for Real Results

Backed by 20+ years of published research and a robust safety profile, CelluThrive™ is GRAS-affirmed and suitable for a wide range of product applications. A single gram of CelluThrive™ Glucarate can drop estradiol levels by 56% compared to the placebo [x]. Similar research showed a 50% reduction in β-glucuronidase enzyme activity, contributing to a total reduction of blood estradiol concentration by 23% [xi].

Product Forms & Formulation Options

• CelluThrive™ CDG (Calcium D-Glucarate): Ideal for capsules and tablets; slow-release delivery.
• CelluThrive™ PHG (Potassium-Hydrogen Glucarate): 100% water soluble for use in powdered beverages, shots, and RTDs.

More Benefits of CelluThrive™

• Hormonal Harmony: Supports healthy estrogen metabolism in both men and women through the elimination of excess estrogen and estrogen mimickers (xenoestrogens) for more stable energy, mood, and sleep during hormonal shifts.
• Muscle Recovery & Performance: Clears exercise-induced waste like ammonia and stress hormones, reduces oxidative stress to support faster recovery, and improves muscle health in active individuals.
• Immune Resilience: Helps promote a more balanced, responsive immune system by detoxifying inflammatory pollutants and cytokine triggers that can cause an immune response.
• Beauty-From-Within: Aids in cellular health by filtering out toxins and chemical pollutants, promoting skin vitality and radiance from the inside out.

Final Word: Rewriting the Wellness Script

Aging isn’t a problem to solve—it’s a new chapter to step into with power and presence. CelluThrive™ gives the body what it needs to transition smoothly, addressing hormonal harmony, estrogen metabolism, and detox at the source. If you’re ready to formulate a product for women’s wellness, male vitality, or hormone health, let CelluThrive™, with its decades of clinical evidence, be the hero of your next brand.

Citations:

1. Archer DF, Nakajima ST, Sawyer AT, Wentworth J, Trupin S, Koltun WD, Gilbert RD, Ellman H. Norethindrone acetate 1.0 milligram and ethinyl estradiol 10 micrograms as an ultra low-dose oral contraceptive. Obstet Gynecol. 2013 Sep;122(3):601-7. [PubMed] [Reference list]
2. Sarfaroj Khan, BHMS, PGD Health Operations. What are phytoestrogens, and what are they used for?. 2022
3. Cleveland Clinic. Overview: What is estrogen? 2022
4. Tolu Oyelowo DC, in Mosby’s Guide to Women’s Health, 2007
5. Hayes, F. J., DeCruz, S., Seminara, S. B., Boepple, P. A., & Crowley, W. F. (2001). Differential regulation of gonadotropin secretion by testosterone in the human male: absence of a negative feedback effect of estradiol. The Journal of Clinical Endocrinology & Metabolism, 86(2), 530–536. https://doi.org/10.1210/jcem.86.2.7251
6. Brandenberger AW, Tee MK, Lee JY, Chao V, Jaffe RB. Tissue distribution of Estrogen Receptors Alpha (ER-alpha) and Beta (ER-alpha) mRNA in the midgestational human fetus. J Clin Endocrinol Metab. 1997;82(10):3509–3512. doi: 10.1210/jc.82.10.3509.
7. Hanausek, M., Walaszek, Z., and Slaga, T. (2003). Detoxifying cancer causing agents to prevent cancer. Integrative Cancer Therapies, 2(2), 139-144.
8. Cline, J.C. (2015). Nutritional aspects of detoxification in clinical practice. Alternative Therapies, 21, 54-62.
9. Sandberg AA, Slaunwhite WR Jr.. Studies on phenolic steroids in human subjects. II. The metabolic fate and hepato-biliary-enteric circulation of C14-estrone and C14-estradiol in women. J Clin Invest. 1957;36(8):1266–1278. doi: 10.1172/JCI103524
10. G Tramontano. A Multi Center, Randomized, Double-Blind, Within Subject Crossover Study to Explore the Safety and Efficacy of D-Glucarate 1000 mg Versus Placebo on Vasomotor, Emotional and Behavioral Symptoms in Symptomatic Perimenopausal Women, Exoden Research Center, 2012.
11. Abou-Issa, H., Dwivedi, C., Curley, R. W., Kirkpatrick, R., Coolemans- Beynen, A., Engineer, F. N., Humphries, K. A., El-Masry, W., and Webb, T. E. (1993). Basis for the antitumor and chemopreventive activities of glucarate and the glucarate–retinoid combination. Anticancer Res. 13, 395–399